Effects of antiendothelin treatment on the early hemodynamic changes in hyperdynamic endotoxemia.

J. Kaszaki, A. Wolfárd, M. Boros, L. Baranyi, H. Okada, S. Nagy

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We have performed a series of experiments to study the effects of a newly developed antisense homology box-derived endothelin (ET) antagonist peptide (ETR-P1/fl) on the early hemodynamic changes in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO) and myocardial contractility (MC) were measured in closed-chest animals. Plasma levels of ET-1,2 were determined by radioimmunassay. A hyperdynamic circulatory response was elicited with a 2-hour infusion of 5.3 micrograms/kg of E. coli endotoxin (ETX). Control and ETX-treated animals received an infusion of ETR-P1/fl (0.1 mg/kg) i.v. ETX treatment decreased MAP and MC, increased initially CO, and a long lasting elevation in the plasma ET level was observed. In ETX-treated animals the administration of ETR-P1/fl significantly prolonged the increase in CO and inhibited the depression of MC. Our results suggest that treatment with the ET antagonist ETR-P1/fl may be advantageous in the early phase of endotoxemia.

Original languageEnglish
Pages (from-to)152-153
Number of pages2
JournalActa Chirurgica Hungarica
Issue number1-4
Publication statusPublished - 1997


ASJC Scopus subject areas

  • Surgery

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