Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats

T. Hajszán, Neil J. MacLusky, Jamie A. Johansen, Cynthia L. Jordan, Csaba Leranth

Research output: Contribution to journalArticle

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Abstract

Recent studies suggest that, in female monkeys and rats, estrogens elicit dendritic spine synapse formation in the prefrontal cortex, an area that, similar to the hippocampus, plays a critical role in cognition. However, whether gonadal hormones induce synaptic remodeling in the male prefrontal cortex remains unknown. Here we report that gonadectomy reduced, whereas administration of 5α-dihydrotestosterone or estradiol-benzoate to castrated male rats increased, the number of medial prefrontal cortical (mPFC) spine synapses, with estradiol-benzoate being less effective than 5α-dihydrotestosterone. To investigate whether the androgen receptor contributes to the mediation of these changes, we compared the response of testicular feminization mutant (Tfm) male rats to that of wild-type animals. The number of mPFC spine synapses in gonadally intact Tfm rats and 5α-dihydrotestosterone-treated castrated Tfm males was considerably reduced compared to intact wild-type animals, whereas the synaptogenic effect of estradiol-benzoate was surprisingly enhanced in Tfm rats. These data are consistent with the hypothesis that remodeling of spine synapses in the prefrontal cortex may contribute to the cognitive effect of gonadal steroids. Our findings in Tfm animals indicate that androgen receptors may mediate a large part of the synaptogenic action of androgens in the mPFC of adult males. However, because this effect of 5α-dihydrotestosterone is not completely lost in Tfm rats, additional mechanisms may also be involved.

Original languageEnglish
Pages (from-to)1963-1967
Number of pages5
JournalEndocrinology
Volume148
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Androgen-Insensitivity Syndrome
Prefrontal Cortex
Synapses
Androgens
Estradiol
Spine
Dihydrotestosterone
Wild Animals
Androgen Receptors
Gonadal Hormones
Dendritic Spines
Cognition
Haplorhini
Hippocampus
Estrogens
Steroids
estradiol 3-benzoate

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats. / Hajszán, T.; MacLusky, Neil J.; Johansen, Jamie A.; Jordan, Cynthia L.; Leranth, Csaba.

In: Endocrinology, Vol. 148, No. 5, 05.2007, p. 1963-1967.

Research output: Contribution to journalArticle

Hajszán, T. ; MacLusky, Neil J. ; Johansen, Jamie A. ; Jordan, Cynthia L. ; Leranth, Csaba. / Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats. In: Endocrinology. 2007 ; Vol. 148, No. 5. pp. 1963-1967.
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