Effects of anandamide (endogen cannabinoid) on anterior pituitary hormone secretion in adult ovariectomized rats

T. Wenger, B. Tóth, Billy R. Martin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

It has been shown that the main psychoactive component of marihuana, Δ9-tetrahydrocannabinol (THC) has mainly inhibitory effects on pituitary luteinizing hormone (LH), prolactin (PRL) and growth hormone (GH) and has no or little effect on follicle stimulating hormone (FSH) secretion. Recently the purification and availability of the putative endogenous ligand for the cannabinoid receptor, anandamide (arachidonyl ethanol-amide, anandamide) (ANA) provided us the opportunity to compare the effects of THC and ANA on the female neuroendocrine system in ovariectomized (OVX) rats. OVX was performed three weeks prior to the experimental period to avoid cyclic differences. OVX rats were injected i.p. with either THC or ANA (0.02mg/kg.b.w./day, respectively) or vehicle for two weeks. The results show that both ANA and THC decrease serum LH level although THC with a higher degree. No significant differences were observed in serum FSH level. Both drugs decreased serum PRL. Serum GH was increased after THC administration and significantly decreased after ANA. The results indicate that ANA and THC alter pituitary hormone secretion, mainly by inhibitory action. The site of action requires further investigations.

Original languageEnglish
Pages (from-to)2057-2063
Number of pages7
JournalLife Sciences
Volume56
Issue number23-24
DOIs
Publication statusPublished - May 5 1995

Fingerprint

Anterior Pituitary Hormones
Dronabinol
Cannabinoids
Rats
Amides
Ethanol
Pituitary Hormones
Follicle Stimulating Hormone
Luteinizing Hormone
Serum
Prolactin
Growth Hormone
Cannabinoid Receptors
Neurosecretory Systems
Cannabis
anandamide
Purification
Availability
Ligands

Keywords

  • anandamide
  • ovariectomy
  • pituitary

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

Cite this

Effects of anandamide (endogen cannabinoid) on anterior pituitary hormone secretion in adult ovariectomized rats. / Wenger, T.; Tóth, B.; Martin, Billy R.

In: Life Sciences, Vol. 56, No. 23-24, 05.05.1995, p. 2057-2063.

Research output: Contribution to journalArticle

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