Effects of amphetamine and haloperidol on avoidance behavior and exploratory activity

G. Kovács, David De Wied

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The effect of graded doses of D-amphetamine and haloperidol were tested on retention of a one trial learning passive avoidance response, on extinction of a pole-jumping active avoidance behavior and on open-field activity. Low doses of amphetamine (10 μg/animal) increased passive avoidance latency when given s.c. 1 h prior to the retention test. Higher doses (20 and 1000 μg/animal) caused a bimodal distribution of avoidance latencies. Haloperidol (0.03 or 1.0 μg/animal) significantly attenuated passive avoidance behavior. Amphetamine caused a delay of extinction of pole-jumping avoidance behavior in a dose-dependent manner (10, 30 or 90 μg per rat). Conversely, haloperidol induced a dose-dependent facilitation of extinction (0.03 or 0.1 μg per rat). Open-field activity was not significantly affected by 30 μg amphetamine or 0.03 μg haloperidol; 90 μg amphetamine significantly increased rearing activity and 0.1 μg haloperidol decreased ambulation. The data show that passive and active avoidance behavior are sensitive measures to test the activity of psychomotor stimulant and neuroleptic drugs. Exploratory behavior allows more specific behavioral effects to be dissociated from locomotor influences.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalEuropean Journal of Pharmacology
Volume53
Issue number1
DOIs
Publication statusPublished - Dec 15 1978

Fingerprint

Avoidance Learning
Haloperidol
Amphetamine
Exploratory Behavior
Antipsychotic Agents
Walking
Psychological Extinction

Keywords

  • Amphetamine
  • Haloperidol
  • Open-field activity
  • Passive and active avoidance behavior

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of amphetamine and haloperidol on avoidance behavior and exploratory activity. / Kovács, G.; De Wied, David.

In: European Journal of Pharmacology, Vol. 53, No. 1, 15.12.1978, p. 103-107.

Research output: Contribution to journalArticle

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