Effects of aldosterone and dexamethasone on atrial natriuretic peptide levels in preoptic and hypothalamic nuclei of adrenalectomized and intact rats

Helmut Geiger, Udo Buhner, M. Palkóvits, Elisabeth Nicklas, Christian Hugo, August Heidland

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of aldosterone and dexamethasone on the concentrations of atrial natriuretic peptide (ANP) in preoptic and hypothalamic nuclei was examined in adrenalectomized and intact rats. Five days after adrenalectomy, increased ANP levels in those brain areas which control water intake, i.e. in the subfornical organ, supraoptic nucleus, and in the so-called hypothalamic drinking centers (perifornical nucleus, lateral hypothalamic area) were measured. In contrast to this, adrenalectomy decreased ANP levels markedly in the organum vasculosum laminae terminalis and preoptic periventricular nucleus, which are reportedly involved in the central regulation of salt and water homeostasis. ANP contents of these two preoptic structures were restored almost completely by daily administration of 0.9% sodium chloride or aldosterone but not dexamethasone. The daily administration of aldosterone elevated ANP levels in the supraoptic, paraventricular and perifornical nuclei as well as in the lateral hypothalamus both in control and adrenalectomized rats. Dexamethasone which was without any significant effect on preoptic and hypothalamic nuclei in control rats elevated ANP levels in the supraoptic and perifornical nuclei and in the lateral hypothalamic area of adrenalectomized animals. Since neither adrenalectomy, nor aldosterone or dexamethasone treatment influenced plasma ANP levels, altered ANP contents measured in preoptic and hypothalamic nuclei may represent a direct effect of adrenal corticoids (mainly aldosterone) on brain ANP-containing neurons which may participate in the control of body fluid and electrolyte homeostasis.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalNeuroendocrinology
Volume53
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Preoptic Area
Atrial Natriuretic Factor
Aldosterone
Dexamethasone
Lateral Hypothalamic Area
Adrenalectomy
Supraoptic Nucleus
Drinking
Homeostasis
Subfornical Organ
Paraventricular Hypothalamic Nucleus
Brain Natriuretic Peptide
Body Fluids
Sodium Chloride
Electrolytes
Adrenal Cortex Hormones
Salts
Neurons
Water
Brain

Keywords

  • Adrenalectomy
  • Aldosterone
  • Atrial natriuretic peptide
  • Dexamethasone
  • Hypothalamic nuclei
  • Preoptic nuclei
  • Radioimmunoassay

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Effects of aldosterone and dexamethasone on atrial natriuretic peptide levels in preoptic and hypothalamic nuclei of adrenalectomized and intact rats. / Geiger, Helmut; Buhner, Udo; Palkóvits, M.; Nicklas, Elisabeth; Hugo, Christian; Heidland, August.

In: Neuroendocrinology, Vol. 53, No. 1, 1991, p. 63-68.

Research output: Contribution to journalArticle

Geiger, Helmut ; Buhner, Udo ; Palkóvits, M. ; Nicklas, Elisabeth ; Hugo, Christian ; Heidland, August. / Effects of aldosterone and dexamethasone on atrial natriuretic peptide levels in preoptic and hypothalamic nuclei of adrenalectomized and intact rats. In: Neuroendocrinology. 1991 ; Vol. 53, No. 1. pp. 63-68.
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