Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl

WI) rats

Viktoria Somogyi, Katalin Peto, Adam Deak, Bence Tanczos, N. Németh

Research output: Contribution to journalArticle

Abstract

Background: Age-and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. Objective: We aimed to investigate the influence of aging and gender on hemorheological parameters in rats. Methods: Coeval male (n = 10) and female (n = 10) Wistar (Crl:WI) rats were followed-up over 15 months. Blood samples were obtained from the lateral tail vein at 3, 4, 5, 9, 12, 15 and 18 months of age. Hematological parameters, red blood cell deformability (elongation under shear), osmotic gradient deformability and erythrocyte aggregation were tested. Body weight and the estrus cycle (in females) were also examined. Results: Erythrocyte aggregation showed age-and gender-related variations. Red blood cell deformability was greater in females and gradually decreased over the 15-month period in both genders. Erythrocyte aggregation was greater in male rats at most ages, but did not show consistent changes with age. Conclusions: The micro-rheological parameters showed age-related alterations with gender differences. The effect of the estrous cycle cannot be excluded in female rats. The results provide reference data for studies of aging in rats and of the mechanism related to age and gender differences in hemorheology.

Original languageEnglish
Pages (from-to)127-140
Number of pages14
JournalBiorheology
Volume54
Issue number5-6
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Rheology
Erythrocyte Aggregation
Erythrocytes
Hemorheology
Estrous Cycle
Estrus
Tail
Veins
Rodentia
Body Weight

Keywords

  • aging
  • gender differences
  • Hemorheology
  • rat
  • red blood cell aggregation
  • red blood cell deformability

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl : WI) rats. / Somogyi, Viktoria; Peto, Katalin; Deak, Adam; Tanczos, Bence; Németh, N.

In: Biorheology, Vol. 54, No. 5-6, 01.01.2018, p. 127-140.

Research output: Contribution to journalArticle

Somogyi, Viktoria ; Peto, Katalin ; Deak, Adam ; Tanczos, Bence ; Németh, N. / Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl : WI) rats. In: Biorheology. 2018 ; Vol. 54, No. 5-6. pp. 127-140.
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