Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantation

Tibor Szük, B. Nagy, Z. Bereczky, Zsolt Koszegi, I. Édes, J. Kappelmayer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Stents represent a thrombogenic surface where one of the earliest events is the deposition of platelets. Activated platelets express neoepitopes that enable them to form homo- and heterotypic aggregates and activate the coagulation system. In this study, we investigated the effects of ad hoc clopidogrel treatment compared to a clopidogrel pretreated group on platelet P-selectin expression. We found that after stent implantation in the ad hoc treated group, P-selectin expression decreased after 1 h, while the initial decrease in platelet count normalized after 4 h. Aspirin non-responsiveness did not influence the results. These data point to the beneficial effect of clopidogrel treatment in reducing platelet reactivity during stenting.

Original languageEnglish
Pages (from-to)344-346
Number of pages3
JournalPlatelets
Volume17
Issue number5
DOIs
Publication statusPublished - Aug 1 2006

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clopidogrel
P-Selectin
Stents
Blood Platelets
Platelet Count
Aspirin

Keywords

  • Clopidogrel
  • Platelet activation
  • Stenting

ASJC Scopus subject areas

  • Hematology
  • Cell Biology

Cite this

Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantation. / Szük, Tibor; Nagy, B.; Bereczky, Z.; Koszegi, Zsolt; Édes, I.; Kappelmayer, J.

In: Platelets, Vol. 17, No. 5, 01.08.2006, p. 344-346.

Research output: Contribution to journalArticle

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AU - Édes, I.

AU - Kappelmayer, J.

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