Effects of acute and chronic fluoxetine treatment on CRH-induced anxiety

C. Thang To, Zsuzsanna E. Anheuer, Gyorgy Bagdy

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The effects of acute and chronic fluoxetine treatment on anxiogenic effect of corticotropin-releasing hormone (CRH) were studied in the social interaction test in male Sprague-Dawley rats. Injection of CRH (100 ng, i.c.v.), fluoxetine (5 mg/kg, i.p.) or their combination had significant anxiogenic effects (decrease in total interaction time and increase in self- grooming) in the social interaction test. The effects of CRH and flouxetine in combination were not additive. Fluoxetine, but not CRH significantly inhibited locomotor activity. After chronic fluoxetine treatment (5 mg/kg/day, 21 days) the acute anxiogenic effects of either CRH or fluoxetine were abolished. Our studies provide evidence for a 5-HT/CRH interaction in the regulation of anxiety.

Original languageEnglish
Pages (from-to)553-555
Number of pages3
Issue number3
Publication statusPublished - Feb 25 1999



  • Anxiety
  • Corticotropin-releasing hormone (CRH)
  • Fluoxetine
  • SSRI antidepressant
  • Serotonin (5- HT)
  • Social interaction test

ASJC Scopus subject areas

  • Neuroscience(all)

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