Effects of ACTH4-10 on self-stimulation behavior in the rat

C. Nyakas, B. Bohus, D. De Wied

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The threshold current evoking self-stimulation or multiples of this current was used to investigate the effect of ACTH4-10 on response performance for brain stimulation reward in the medial septum (MS) and the medial forebrain bundle (MFB). ACTH4-10 in a dose of 50 μg administered SC enhanced bar-pressing for low intensity stimulation but failed to change self-stimulation rates when the base-line rate exceeded 100 responses per 6 min. The peptide lowered the threshold for producing self-stimulation but only in the MS. When an ascending sequence of threshold multiples was used within a session, ACTH4-10 treatment resulted in an increase in response rate at 1.2 and 1.5 threshold multiples and a decrease at 3.0 times the threshold but only in the MS. The results indicate that ACTH4-10 facilitated response performance at a low response rate by enhancing the rewarding effect of brain stimulation. Furthermore, the peptide changed the response pattern which normally followed reinforcement shift in the MS.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalPhysiology and Behavior
Volume24
Issue number4
DOIs
Publication statusPublished - 1980

Fingerprint

Self Stimulation
Medial Forebrain Bundle
Peptides
Brain
Reward
Therapeutics

Keywords

  • ACTH
  • Medial forebrain bundle
  • Medial septum
  • Rate-dependent effect
  • Reinforcement shift
  • Self-stimulation

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Effects of ACTH4-10 on self-stimulation behavior in the rat. / Nyakas, C.; Bohus, B.; De Wied, D.

In: Physiology and Behavior, Vol. 24, No. 4, 1980, p. 759-764.

Research output: Contribution to journalArticle

Nyakas, C. ; Bohus, B. ; De Wied, D. / Effects of ACTH4-10 on self-stimulation behavior in the rat. In: Physiology and Behavior. 1980 ; Vol. 24, No. 4. pp. 759-764.
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