Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells

Sandrine Alibert, Christiane Santelli-Rouvier, Madeleine Castaing, Michel Berthelot, Gabriella Spengler, Jozsef Molnar, Jacques Barbe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was tested with the aim to quantify the effect observed on drug efflux. Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents.

Original languageEnglish
Pages (from-to)253-263
Number of pages11
JournalEuropean Journal of Medicinal Chemistry
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Keywords

  • 9,10-Dihydro-9,10-ethano and ethenoanthracene derivatives
  • Cancer cells
  • Chemosensitizers
  • Drug efflux
  • Multidrug resistance
  • P-glycoprotein
  • Structure activity relationships

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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