Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants

G. Telegdy, M. Fekete, M. Balazs, T. Kadar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of a new antidepressant drug, EGYT-475 (1-benzyl-4-(2'-pyridylcarbonyl)-piperazine) on the acquisition and extinction of conditioned avoidance behavior following short and long-term treatment were studied in rats. The effects were compared with those of amitriptyline, imipramine and desipramine. In a sixty-day acquisition period, EGYT-475 in a 200 mg/kg dose p.o facilitated the acquisition, while amitriptyline, imipramine and desipramine either had no effect or impaired the acquisition, depending upon the dose used. In a six-day extinction period, EGYT-475 delayed the extinction following either oral or intraperitoneal administration, while amitriptyline, imipramine, and desipramine in various doses facilitated the extinction. On prolonged treatment the delayed extinction was maintained even after 42 days in animals treated with EGYT-475. The results indicate that EGYT-475, in contrast to tricyclic antidepressants, does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it.

Original languageEnglish
Pages (from-to)50-59
Number of pages10
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume266
Issue number1
Publication statusPublished - 1983

Fingerprint

Avoidance Learning
Tricyclic Antidepressive Agents
Antidepressive Agents
Desipramine
Amitriptyline
Imipramine
Psychological Extinction
EGYT 475

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants. / Telegdy, G.; Fekete, M.; Balazs, M.; Kadar, T.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 266, No. 1, 1983, p. 50-59.

Research output: Contribution to journalArticle

@article{5286b893932246a3ae48cae0a388c9a3,
title = "Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants",
abstract = "The effects of a new antidepressant drug, EGYT-475 (1-benzyl-4-(2'-pyridylcarbonyl)-piperazine) on the acquisition and extinction of conditioned avoidance behavior following short and long-term treatment were studied in rats. The effects were compared with those of amitriptyline, imipramine and desipramine. In a sixty-day acquisition period, EGYT-475 in a 200 mg/kg dose p.o facilitated the acquisition, while amitriptyline, imipramine and desipramine either had no effect or impaired the acquisition, depending upon the dose used. In a six-day extinction period, EGYT-475 delayed the extinction following either oral or intraperitoneal administration, while amitriptyline, imipramine, and desipramine in various doses facilitated the extinction. On prolonged treatment the delayed extinction was maintained even after 42 days in animals treated with EGYT-475. The results indicate that EGYT-475, in contrast to tricyclic antidepressants, does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it.",
author = "G. Telegdy and M. Fekete and M. Balazs and T. Kadar",
year = "1983",
language = "English",
volume = "266",
pages = "50--59",
journal = "Archives Internationales de Pharmacodynamie et de Therapie",
issn = "0003-9780",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants

AU - Telegdy, G.

AU - Fekete, M.

AU - Balazs, M.

AU - Kadar, T.

PY - 1983

Y1 - 1983

N2 - The effects of a new antidepressant drug, EGYT-475 (1-benzyl-4-(2'-pyridylcarbonyl)-piperazine) on the acquisition and extinction of conditioned avoidance behavior following short and long-term treatment were studied in rats. The effects were compared with those of amitriptyline, imipramine and desipramine. In a sixty-day acquisition period, EGYT-475 in a 200 mg/kg dose p.o facilitated the acquisition, while amitriptyline, imipramine and desipramine either had no effect or impaired the acquisition, depending upon the dose used. In a six-day extinction period, EGYT-475 delayed the extinction following either oral or intraperitoneal administration, while amitriptyline, imipramine, and desipramine in various doses facilitated the extinction. On prolonged treatment the delayed extinction was maintained even after 42 days in animals treated with EGYT-475. The results indicate that EGYT-475, in contrast to tricyclic antidepressants, does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it.

AB - The effects of a new antidepressant drug, EGYT-475 (1-benzyl-4-(2'-pyridylcarbonyl)-piperazine) on the acquisition and extinction of conditioned avoidance behavior following short and long-term treatment were studied in rats. The effects were compared with those of amitriptyline, imipramine and desipramine. In a sixty-day acquisition period, EGYT-475 in a 200 mg/kg dose p.o facilitated the acquisition, while amitriptyline, imipramine and desipramine either had no effect or impaired the acquisition, depending upon the dose used. In a six-day extinction period, EGYT-475 delayed the extinction following either oral or intraperitoneal administration, while amitriptyline, imipramine, and desipramine in various doses facilitated the extinction. On prolonged treatment the delayed extinction was maintained even after 42 days in animals treated with EGYT-475. The results indicate that EGYT-475, in contrast to tricyclic antidepressants, does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it.

UR - http://www.scopus.com/inward/record.url?scp=0021047625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021047625&partnerID=8YFLogxK

M3 - Article

C2 - 6667064

AN - SCOPUS:0021047625

VL - 266

SP - 50

EP - 59

JO - Archives Internationales de Pharmacodynamie et de Therapie

JF - Archives Internationales de Pharmacodynamie et de Therapie

SN - 0003-9780

IS - 1

ER -