Effects of a 72-hour prostacyclin infusion on the hormone levels in patients with obliterative arterial disease

G. Irsy, G. Blaskó, M. Góth, I. Szabolcs, B. Gachályi, G. Szilágyi

Research output: Contribution to journalArticle

Abstract

Effects of a 72-h prostacyclin (PGI2) infusion (5 ng/kg/min) on hormone levels were studied in 11 patients (5 males, and 6 females) suffering from obliterative arterial disease of the lower extremities. ACTH, cortisol, TSH, prolactin (Prl), GH, LH, FSH, T3, T4, calcitonin, parathyroid hormone (PTH), insulin, plasma renin activity (PRA), aldosterone and testosterone levels were measured at -15, 0, 30, 120, 240 min and 24, 48, 72 and 96 h after the infusion. During the first 240 min Prl and GH levels showed an increase that was thought to be either an effect of release of hormones or a consequence of stress. At the same time the thyroid hormones, T3, T4 and calcitonin decreased, presumably owing to an alteration in the blood flow to the thyroid gland. All these hormone levels returned to normal at 24 h in spite of the infusion continuing. PRA increased only during the second half of the infusion. No changes were found in the levels of ACTH, cortisol, TSH, LH, FSH, PTH, insulin, aldosterone and testosterone during the infusion. Five diabetics showed the same hormonal changes as the non-diabetics and their blood sugar levels remained unaffected during and after the procedure.

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalActa Endocrinologica
Volume110
Issue number2
Publication statusPublished - 1985

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Epoprostenol
Calcitonin
Hormones
Aldosterone
Parathyroid Hormone
Renin
Prolactin
Adrenocorticotropic Hormone
Hydrocortisone
Testosterone
Insulin
Triiodothyronine
Thyroxine
Blood Glucose
Lower Extremity
Thyroid Gland

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effects of a 72-hour prostacyclin infusion on the hormone levels in patients with obliterative arterial disease. / Irsy, G.; Blaskó, G.; Góth, M.; Szabolcs, I.; Gachályi, B.; Szilágyi, G.

In: Acta Endocrinologica, Vol. 110, No. 2, 1985, p. 176-181.

Research output: Contribution to journalArticle

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