Effects of β-/Tyr9/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats

M. Fekete, G. Telegdy, A. V. Schally, D. H. Coy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalNeuropeptides
Volume1
Issue number5
DOIs
Publication statusPublished - 1981

Fingerprint

Melanocyte-Stimulating Hormones
Catecholamines
Rats
Brain
Serotonin
Amygdala
Pargyline
Mesencephalon
Hypothalamus
Tyrosine
Dopamine
Norepinephrine

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Effects of β-/Tyr9/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats. / Fekete, M.; Telegdy, G.; Schally, A. V.; Coy, D. H.

In: Neuropeptides, Vol. 1, No. 5, 1981, p. 377-382.

Research output: Contribution to journalArticle

@article{c23e85d5d3c54ceb8438eb1438d6a644,
title = "Effects of β-/Tyr9/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats",
abstract = "The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.",
author = "M. Fekete and G. Telegdy and Schally, {A. V.} and Coy, {D. H.}",
year = "1981",
doi = "10.1016/0143-4179(81)90025-1",
language = "English",
volume = "1",
pages = "377--382",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "5",

}

TY - JOUR

T1 - Effects of β-/Tyr9/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats

AU - Fekete, M.

AU - Telegdy, G.

AU - Schally, A. V.

AU - Coy, D. H.

PY - 1981

Y1 - 1981

N2 - The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.

AB - The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.

UR - http://www.scopus.com/inward/record.url?scp=0019860020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019860020&partnerID=8YFLogxK

U2 - 10.1016/0143-4179(81)90025-1

DO - 10.1016/0143-4179(81)90025-1

M3 - Article

VL - 1

SP - 377

EP - 382

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 5

ER -