Effects of β-adrenergic inhibitors on noradrenaline and adrenaline metabolism in brain regions of the rat

Ágnes Simonyi, Béla Kanyicska, Tibor Szentendrei, M. Fekete

Research output: Contribution to journalArticle

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Abstract

Chloranolol (5 mg/kg i.p.) retarted the disappearance of noradrenaline induced by the dopamine-β-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) was effective only in the hypothalamus and in the lateral reticular nucleus. The DBH inhibitor-caused accumulation of dopamine was also inhibited by chloranolol in the solitary tract nucleus. Chloranolol and propranolol were able to antagonize the fall in adrenaline concentration due to the phenylethanolamine-N-methyltransferase (PNMT) inhibitor, Lilly 87130, only in the region of the solitary tract nucleus. The data suggest that β-adrenergic inhibitors reduce nonadrenaline and adrenaline turnover in the central nervous system, most characteristically in the solitary tract nucleus and that this effect is possibly related to their antihypertensive effectiveness.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalEuropean Journal of Pharmacology
Volume98
Issue number2
DOIs
Publication statusPublished - Feb 17 1984

Fingerprint

Solitary Nucleus
Adrenergic Agents
Epinephrine
Norepinephrine
LY 87130
Brain
Propranolol
Dopamine
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide
Phenylethanolamine N-Methyltransferase
Lateral Hypothalamic Area
Mixed Function Oxygenases
varespladib methyl
Antihypertensive Agents
Hypothalamus
Central Nervous System
tobanum

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of β-adrenergic inhibitors on noradrenaline and adrenaline metabolism in brain regions of the rat. / Simonyi, Ágnes; Kanyicska, Béla; Szentendrei, Tibor; Fekete, M.

In: European Journal of Pharmacology, Vol. 98, No. 2, 17.02.1984, p. 285-288.

Research output: Contribution to journalArticle

Simonyi, Ágnes ; Kanyicska, Béla ; Szentendrei, Tibor ; Fekete, M. / Effects of β-adrenergic inhibitors on noradrenaline and adrenaline metabolism in brain regions of the rat. In: European Journal of Pharmacology. 1984 ; Vol. 98, No. 2. pp. 285-288.
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