Effects and side-effects of viral RNA silencing suppressors on short RNAs

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

In eukaryotes, short RNAs play a crucial regulatory role in many processes including development, maintenance of genome stability and antiviral responses. These different but overlapping RNA-guided pathways are collectively termed 'RNA silencing'. To counteract an antiviral RNA silencing response, plant viruses express silencing suppressor proteins. Recent results have shown that silencing suppressors operate by modifying the accumulation and/or activity of short RNAs involved in the antiviral response. Because RNA silencing pathways intersect, silencing suppressors can also inhibit other short-RNA-regulated pathways. Thus, suppressors contribute to viral symptoms. These findings fuel further research to test whether certain symptoms caused by animal viruses are also manifestations of altered RNA regulatory pathways.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalTrends in Plant Science
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2004

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Viral RNA
RNA Interference
RNA interference
adverse effects
RNA
Antiviral Agents
Plant Viruses
Genomic Instability
plant viruses
Eukaryota
eukaryotic cells
Maintenance
Viruses
genome
Research
Proteins
proteins
testing

ASJC Scopus subject areas

  • Genetics

Cite this

Effects and side-effects of viral RNA silencing suppressors on short RNAs. / Silhavy, D.; Burgyán, J.

In: Trends in Plant Science, Vol. 9, No. 2, 02.2004, p. 76-83.

Research output: Contribution to journalArticle

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