Effectiveness of tiazofurin (Nsc 286193) in treating disseminated tumor cells and micrometastases in mice

K. Lapis, J. Pcipay, S. Paku

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Abstract

The authors studied the metastasis-inhibiting effect of various dosages of tiazofurin in mice inoculated with a low (LLT) and a highly (LLT HH) metastatic variant of the Lewis lung carcinoma. The tumor cells were inoculated intravenously (lung colony assay), intramuscularly (muscle-lung metastasis model), and intrasplenically (spleen-liver metastasis model), respectively. In the lung colony assay the tiazofurin proved to be curative. In the muscle-lung and the spleen-liver model the tiazofurin treatment, started after the removal of the parent tumor, drastically decreased the number of métastasés in both model systems and brought about a significant prolongation of the survival time in the spleen-liver model. Authors suggest the tiazofurin as one of the most promising candidates for metastasis prevention and inhibition in human beings, too.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalOncology (Switzerland)
Volume47
Issue number4
DOIs
Publication statusPublished - Jan 1 1990

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Keywords

  • Chemotherapy of métastasés
  • Lewis lung carcinoma
  • Metastasis inhibition
  • Tiazofurin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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