A glükokortikoid mometazon furoát orrspray formában való adásának hatása szezonális allergiás rhinitisben.

Translated title of the contribution: Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis

P. Magyar, I. Herjavecz, A. Hirschberg, P. Kraszkó, E. Mohácsi, K. Nékám, K. Fónay, G. Berta, Z. Györi, Z. Márk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The clinical effect and tolerance of momethasone furoate (MF) glucocorticoid nasal spray (MFNS) were studied in 14-70 year-old patients suffering from seasonal allergic rhinitis. The patients administered daily one (morning) dose, 100 micrograms each, of MF into both nostrils, for a period of 14 days. They did not use other medicines affecting nasal symptoms. Nasal symptoms (nasal discharge, nasal obstruction, nasal itching, sneezing) and non-nasal symptoms (lacrimation, eye itching/burning sensation, palatal itching, ear itching, general itching), scored 0 to 3, and serving as a basis for evaluating the effect, were registered before treatment (day 1) and at visits on 3, 7 and 14th day. Of the 196 patients involved in the open multicentric study, 188 completed the study. The total average nasal symptom scores decreased, already after 3 days of treatment, from 8.7 to 4.1 and to 1.6 by the 14th day. Decrease of non-nasal symptoms was also conspicuous, however, lacrimation persisted in 57 of 188 cases, while eye itching--mainly in moderate and mild form--in 90 cases. The general condition of rhinitis before the treatment was evaluated by the examiners as severe or very severe in 155 cases (82%), as symptom-free (99 cases) on day 14 in, and mild (71 cases), in 170 cases (90%). The therapeutic effect was considered by both, patients and physician, as excellent, in 106 (56%) and 115 (61%) cases, resp. and as good in 63 (34%) and 56 cases (30%). Side-effects were mostly mild and transitory. Treatment was not discontinued due to side-effect in any of the cases. Based on the results, MFNS, administered in a single daily dose of 200 micrograms, has proved to be an effective and safe glucocorticoid preparation, also easy to use locally, in the treatment of allergic rhinitis.

Translated title of the contributionEffectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis
Original languageHungarian
Pages (from-to)1407-1411
Number of pages5
JournalOrvosi hetilap
Volume141
Issue number25
Publication statusPublished - Jun 18 2000

ASJC Scopus subject areas

  • Medicine(all)

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    Magyar, P., Herjavecz, I., Hirschberg, A., Kraszkó, P., Mohácsi, E., Nékám, K., Fónay, K., Berta, G., Györi, Z., & Márk, Z. (2000). A glükokortikoid mometazon furoát orrspray formában való adásának hatása szezonális allergiás rhinitisben. Orvosi hetilap, 141(25), 1407-1411.