Hatékony somatostatinanalóg-kezelés hormonálisan inaktív carcinoid daganatos betegben: A szérum-chromogranin - A alkalmazása a klinikai követés során

Translated title of the contribution: Effective treatment of a hormonally inactive carcinoid tumour with somatostatin analogues: Application of serum chromogranin A for clinical follow-up

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4 Citations (Scopus)

Abstract

Introduction: Hormonally inactive carcinoids represent a significant proportion of all carcinoids; tumours. Classical biochemical and hormonal parameters are not suitable for the diagnosis and follow-up of these turnouts. However, the turnour marker chromogranin A that is characteristic for several neuroendocrine tumours and secreted by the majority of these turnours as well, may offer a better means of diagnosis and follow-up. Somatostatin receptors are expressed by hormonally inactive carcinoids and the presence of these receptors has important diagnostic and therapeutic consequences. Case report: The authors present the history of a patient with a hormonally inactive bronchial carcinoid tumour. After surgical removal of the bronchial carcinoid, liver metastascs developed which were found to be somatostatin receptor positive. Somatostatin analogue treatment was introduced, followed by Yttrium-isotope labelled somatostatin analogue therapy. Serum chromogranin A was elevated before somatostatin treatment, and gradually decreased in parallel with therapy. The size of liver metastases remained unchanged during treatment. Conclusions: Chromogranin A can be efficiently applied for the clinical follow-up of hormonally inactive carcinoid tumours. Somatostatin analogues may be effective for preventing tumour progression not only in hormone-secreting but also in hormonally inactive carcinoid tumours.

Translated title of the contributionEffective treatment of a hormonally inactive carcinoid tumour with somatostatin analogues: Application of serum chromogranin A for clinical follow-up
Original languageHungarian
Pages (from-to)2343-2346
Number of pages4
JournalOrvosi hetilap
Volume148
Issue number49
DOIs
Publication statusPublished - Dec 9 2007

ASJC Scopus subject areas

  • Medicine(all)

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