Effective temperature of mutations

I. Derényi, Gergely J. Szöllosi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Biological macromolecules experience two seemingly very different types of noise acting on different time scales: (i) point mutations corresponding to changes in molecular sequence and (ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and model lattice proteins, we show that the effects of single point mutations are statistically indistinguishable from those of an increase in temperature by a few tens of kelvins. The existence of such an effective mutational temperature establishes a quantitative connection between robustness to genetic (mutational) and environmental (thermal) perturbations.

Original languageEnglish
Article number058101
JournalPhysical Review Letters
Volume114
Issue number5
DOIs
Publication statusPublished - Feb 3 2015

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mutations
Point Mutation
Hot Temperature
Mutation
Temperature
MicroRNAs
macromolecules
Noise
proteins
perturbation
temperature
Proteins

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

Effective temperature of mutations. / Derényi, I.; Szöllosi, Gergely J.

In: Physical Review Letters, Vol. 114, No. 5, 058101, 03.02.2015.

Research output: Contribution to journalArticle

Derényi, I. ; Szöllosi, Gergely J. / Effective temperature of mutations. In: Physical Review Letters. 2015 ; Vol. 114, No. 5.
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