Effective Chemoradiotherapy without Additive Toxicity in Locoregionally Advanced Head and Neck Cancer

Beatrix Nagy, J. Molnár, Laszlo Rovo, Robert Paczona, L. Thurzó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A previous preclinical study revealed that the maximum additive effect between chemotherapy (CT) and irradiation (RT) occurred at a low level of CT. Therapy was therefore designed with an oral drug daily given in combination with RT in order to determine the efficacy and toxicity. Locoregionally advanced head and neck tumor patients were treated with simultaneous RT and CT. RT was administered 5 times per week at 2 Gy per fraction to a total dose of 70 Gy. Throughout the treatment 30 mg/kg Tegafur was given daily orally. In the period between 2000 and 2002, 50 patients were enrolled. In 60%, complete remission was attained with an overall response rate of 94%. Acute mucositis of grade 2 or 3 was observed in 56% (28 patients), while gastrointestinal and hematological toxicity of grade 2 or 3 occured in 8% (4 patients). Because of side-effects, the duration of treatment was at most 2 weeks long. Toxicity was eliminated quickly by careful supportive therapy. In conclusion, it is considered that oral low-dose CT in combination with RT is an efficient and simple mode of treatment for locally advanced head and neck tumor patients with a poor prognosis.

Original languageEnglish
Pages (from-to)4329-4332
Number of pages4
JournalAnticancer Research
Volume23
Issue number5 B
Publication statusPublished - Sep 2003

Fingerprint

Chemoradiotherapy
Head and Neck Neoplasms
Drug Therapy
Neck
Head
Tegafur
Therapeutics
Mucositis
Combination Drug Therapy
Neoplasms
Pharmaceutical Preparations

Keywords

  • Chemoradiotherapy
  • Head and neck cancer
  • Low-dose chemotherapy
  • Tegafur
  • Tolerability

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effective Chemoradiotherapy without Additive Toxicity in Locoregionally Advanced Head and Neck Cancer. / Nagy, Beatrix; Molnár, J.; Rovo, Laszlo; Paczona, Robert; Thurzó, L.

In: Anticancer Research, Vol. 23, No. 5 B, 09.2003, p. 4329-4332.

Research output: Contribution to journalArticle

@article{a6ddb0abbb3841b7a65640ddeecc8402,
title = "Effective Chemoradiotherapy without Additive Toxicity in Locoregionally Advanced Head and Neck Cancer",
abstract = "A previous preclinical study revealed that the maximum additive effect between chemotherapy (CT) and irradiation (RT) occurred at a low level of CT. Therapy was therefore designed with an oral drug daily given in combination with RT in order to determine the efficacy and toxicity. Locoregionally advanced head and neck tumor patients were treated with simultaneous RT and CT. RT was administered 5 times per week at 2 Gy per fraction to a total dose of 70 Gy. Throughout the treatment 30 mg/kg Tegafur was given daily orally. In the period between 2000 and 2002, 50 patients were enrolled. In 60{\%}, complete remission was attained with an overall response rate of 94{\%}. Acute mucositis of grade 2 or 3 was observed in 56{\%} (28 patients), while gastrointestinal and hematological toxicity of grade 2 or 3 occured in 8{\%} (4 patients). Because of side-effects, the duration of treatment was at most 2 weeks long. Toxicity was eliminated quickly by careful supportive therapy. In conclusion, it is considered that oral low-dose CT in combination with RT is an efficient and simple mode of treatment for locally advanced head and neck tumor patients with a poor prognosis.",
keywords = "Chemoradiotherapy, Head and neck cancer, Low-dose chemotherapy, Tegafur, Tolerability",
author = "Beatrix Nagy and J. Moln{\'a}r and Laszlo Rovo and Robert Paczona and L. Thurz{\'o}",
year = "2003",
month = "9",
language = "English",
volume = "23",
pages = "4329--4332",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5 B",

}

TY - JOUR

T1 - Effective Chemoradiotherapy without Additive Toxicity in Locoregionally Advanced Head and Neck Cancer

AU - Nagy, Beatrix

AU - Molnár, J.

AU - Rovo, Laszlo

AU - Paczona, Robert

AU - Thurzó, L.

PY - 2003/9

Y1 - 2003/9

N2 - A previous preclinical study revealed that the maximum additive effect between chemotherapy (CT) and irradiation (RT) occurred at a low level of CT. Therapy was therefore designed with an oral drug daily given in combination with RT in order to determine the efficacy and toxicity. Locoregionally advanced head and neck tumor patients were treated with simultaneous RT and CT. RT was administered 5 times per week at 2 Gy per fraction to a total dose of 70 Gy. Throughout the treatment 30 mg/kg Tegafur was given daily orally. In the period between 2000 and 2002, 50 patients were enrolled. In 60%, complete remission was attained with an overall response rate of 94%. Acute mucositis of grade 2 or 3 was observed in 56% (28 patients), while gastrointestinal and hematological toxicity of grade 2 or 3 occured in 8% (4 patients). Because of side-effects, the duration of treatment was at most 2 weeks long. Toxicity was eliminated quickly by careful supportive therapy. In conclusion, it is considered that oral low-dose CT in combination with RT is an efficient and simple mode of treatment for locally advanced head and neck tumor patients with a poor prognosis.

AB - A previous preclinical study revealed that the maximum additive effect between chemotherapy (CT) and irradiation (RT) occurred at a low level of CT. Therapy was therefore designed with an oral drug daily given in combination with RT in order to determine the efficacy and toxicity. Locoregionally advanced head and neck tumor patients were treated with simultaneous RT and CT. RT was administered 5 times per week at 2 Gy per fraction to a total dose of 70 Gy. Throughout the treatment 30 mg/kg Tegafur was given daily orally. In the period between 2000 and 2002, 50 patients were enrolled. In 60%, complete remission was attained with an overall response rate of 94%. Acute mucositis of grade 2 or 3 was observed in 56% (28 patients), while gastrointestinal and hematological toxicity of grade 2 or 3 occured in 8% (4 patients). Because of side-effects, the duration of treatment was at most 2 weeks long. Toxicity was eliminated quickly by careful supportive therapy. In conclusion, it is considered that oral low-dose CT in combination with RT is an efficient and simple mode of treatment for locally advanced head and neck tumor patients with a poor prognosis.

KW - Chemoradiotherapy

KW - Head and neck cancer

KW - Low-dose chemotherapy

KW - Tegafur

KW - Tolerability

UR - http://www.scopus.com/inward/record.url?scp=0344009622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344009622&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 4329

EP - 4332

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5 B

ER -