The effect of bicarbonate infusion upon the acid base balance and CO2 content of brain tissue was studied in hemorrhagic shock in dogs. When physiological saline infusion is given in hemorrhage, a similar but more moderate acidosis develops as compared with untreated dogs. Among the brain regions studied, only the hypothalamus displayed a considerable rise in CO2 at the end of the bleeding. Two hr after retransfusion, beside a marked hypercapnia of the hypothalamus, a significant increase in CO2 level was observed in the frontal and occipital cortex. During hemorrhage, the development of acidosis can be prevented by appropriate bicarbonate infusion. At the end of the bleeding, no tissue hypercapnia was found in any of the brain regions, and 2 hr after retransfusion, a slight CO2 accumulation could be demonstrated only in the hypothalamus. Physiological saline infusion seems to reduce, by an alteration of blood viscosity, the pathological changes arising in the cells. In view of the favorable effect of bicarbonate infusion, acidosis is assumed to represent an aggravating factor in the deterioration of cell metabolism.
|Number of pages||11|
|Journal||Acta physiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1974|
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