Effect on cadmium toxicity of substances influencing reticuloendothelial activity

G. Lazar, D. Serra, B. Tuchweber

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In female rats, zymosan and methyl palmitate completely abolished mortality and significantly decreased the lesions in the liver, Gasserian ganglion and ovaries induced by cadmium chloride (CdCl2); in males, they considerably diminished testicular hemorrhage and necrosis. Triolein and gadolinium chloride (GdCl3) were much less effective in these respects. Pretreatment with zymosan or methyl palmitate accelerated the plasma clearance of 109Cd in females. The hepatic uptake of this heavy metal was increased, probably because of decreased biliary excretion. Animals pretreated with zymosan or methyl palmitate showed significantly less cadmium in the stomach, small intestines and lung than controls. The protective actions of these 2 compounds seem to be independent of their influence upon reticuloendothelial activity.

Original languageEnglish
Pages (from-to)367-376
Number of pages10
JournalToxicology and Applied Pharmacology
Volume29
Issue number3
DOIs
Publication statusPublished - 1974

Fingerprint

Zymosan
Cadmium
Toxicity
Triolein
Cadmium Chloride
Trigeminal Ganglion
Liver
Heavy Metals
Small Intestine
Rats
Ovary
Stomach
Animals
Necrosis
Hemorrhage
Plasmas
Lung
Mortality
methyl palmitate

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Effect on cadmium toxicity of substances influencing reticuloendothelial activity. / Lazar, G.; Serra, D.; Tuchweber, B.

In: Toxicology and Applied Pharmacology, Vol. 29, No. 3, 1974, p. 367-376.

Research output: Contribution to journalArticle

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