Effect of X-irradiation on adenylate cyclase activity and cyclic AMP contents of primary human fibroblasts

Z. Somosy, A. Takats, T. Kubasova, F. Sudar, G. J. Koteles

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Abstract

Ionizing radiation provokes an increase of the cAMP level in several organs and body fluids. After reviewing the relevant literature we present the results of our own experiments on primary human fibroblasts. X-irradiation at doses of 0.5 and 2.5 Gy in vitro evoked a rapid and reversible increase of adenylate cyclase enzyme activity. A significant increase in cAMP level of these cells was also observed. Adenylate cyclase was usually localized basolaterally on the surface of unirradiated cells, while irradiation resulted in a modification of distribution, i.e., the enzyme activity also appeared in apical localization.

Original languageEnglish
Pages (from-to)2165-2172
Number of pages8
JournalScanning Microscopy
Volume2
Issue number4
Publication statusPublished - Dec 1 1988

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ASJC Scopus subject areas

  • Instrumentation

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