Effect of water-soluble β-cyclodextrin polymer on the lipophilicity of polymyxine examined by reversed-phase thin-layer chromatography

T. Cserháti, Barna Bordás, Éva Fenyvesi, Jósef Szejtli

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Thin-layer chromatography has shown that the water-soluble β-cyclodextrin polymer forms inclusion complexes with the antibiotic polymyxine, reducing its lipophilicity and its adsorption energy on silica gel. A lower dielectric constant and increasing salt concentration of the solution as well as greater cation radii counteract the complex formation.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of Chromatography A
Volume259
Issue numberC
DOIs
Publication statusPublished - 1983

Fingerprint

Thin layer chromatography
Silica Gel
Reverse-Phase Chromatography
Thin Layer Chromatography
Adsorption
Cations
Permittivity
Salts
Anti-Bacterial Agents
Water
cyclodextrin polymer

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Effect of water-soluble β-cyclodextrin polymer on the lipophilicity of polymyxine examined by reversed-phase thin-layer chromatography. / Cserháti, T.; Bordás, Barna; Fenyvesi, Éva; Szejtli, Jósef.

In: Journal of Chromatography A, Vol. 259, No. C, 1983, p. 107-110.

Research output: Contribution to journalArticle

@article{428331c7b3304a9cb19250c6d06208ba,
title = "Effect of water-soluble β-cyclodextrin polymer on the lipophilicity of polymyxine examined by reversed-phase thin-layer chromatography",
abstract = "Thin-layer chromatography has shown that the water-soluble β-cyclodextrin polymer forms inclusion complexes with the antibiotic polymyxine, reducing its lipophilicity and its adsorption energy on silica gel. A lower dielectric constant and increasing salt concentration of the solution as well as greater cation radii counteract the complex formation.",
author = "T. Cserh{\'a}ti and Barna Bord{\'a}s and {\'E}va Fenyvesi and J{\'o}sef Szejtli",
year = "1983",
doi = "10.1016/S0021-9673(01)87983-8",
language = "English",
volume = "259",
pages = "107--110",
journal = "Journal of Chromatography",
issn = "0021-9673",
publisher = "Elsevier",
number = "C",

}

TY - JOUR

T1 - Effect of water-soluble β-cyclodextrin polymer on the lipophilicity of polymyxine examined by reversed-phase thin-layer chromatography

AU - Cserháti, T.

AU - Bordás, Barna

AU - Fenyvesi, Éva

AU - Szejtli, Jósef

PY - 1983

Y1 - 1983

N2 - Thin-layer chromatography has shown that the water-soluble β-cyclodextrin polymer forms inclusion complexes with the antibiotic polymyxine, reducing its lipophilicity and its adsorption energy on silica gel. A lower dielectric constant and increasing salt concentration of the solution as well as greater cation radii counteract the complex formation.

AB - Thin-layer chromatography has shown that the water-soluble β-cyclodextrin polymer forms inclusion complexes with the antibiotic polymyxine, reducing its lipophilicity and its adsorption energy on silica gel. A lower dielectric constant and increasing salt concentration of the solution as well as greater cation radii counteract the complex formation.

UR - http://www.scopus.com/inward/record.url?scp=0020505398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020505398&partnerID=8YFLogxK

U2 - 10.1016/S0021-9673(01)87983-8

DO - 10.1016/S0021-9673(01)87983-8

M3 - Article

AN - SCOPUS:0020505398

VL - 259

SP - 107

EP - 110

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

IS - C

ER -