Effect of various organic modifiers on the determination of the hydrophobicity parameters of non-homologous series of anticancer drugs

Esther Forga ́cs, Tibor Cserha ́ti

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The lipophilicities and specific hydrophobic surface areas of 21 commercial anticancer drugs were determined by means of reversed-phase thin-layer chromatography using methanol, ethanol, 1-propanol, 2-propanol, acetonitrile, dioxane and tetrahydrofuran as organic modifiers at various concentrations. The data were evaluated by various multivariate mathematical-statistical methods such as the spectral mapping technique and principal component analysis followed by two-dimensional non-linear mapping, varimax rotation and cluster analysis. The results indicate that the solvent strength and selectivity of organic modifiers are strongly related to the steric characteristics of the solvent molecule, suggesting competition between the anticancer drugs and solvent molecules for the hydrophobic surface of the stationary phase. It was established that for the evaluation of large retention data matrices the use of principal component analysis followed by two-dimensional non-linear mapping provides more information than one-dimensional cluster analysis.

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalJournal of Chromatography A
Volume697
Issue number1-2
DOIs
Publication statusPublished - Apr 21 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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