Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study

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2 Citations (Scopus)

Abstract

The objective of the study was to check the effect of the combination of metronidazole and miconazole (M+M) for the prevention of sexually transmitted infections/disorders related preterm delivery/birth. Antiprotozoal vaginal metronidazole was not able to prevent preterm birth, while the antifungal topical miconazole use showed some reduction in preterm birth in our previous studies. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was used for the evaluation of the combination of M + M for birth outcomes. Of 38,151 controls, 846 (2.2%) had treatment with vaginal tablet of M + M for vaginal infections. The prevalence of preterm birth was 9.5% after this treatment compared with the 9.2% of preterm birth in the untreated group. Thus the combination of M + M was not able to reduce the preterm birth associated with vulvovaginal infections/disorders.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume272
Issue number4
DOIs
Publication statusPublished - Dec 1 2005

Keywords

  • Metronidazole and miconazole
  • Preterm birth
  • Sexually transmitted infections

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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