Effect of two synthetic α-gliadin peptides on lymphocytes in celiac disease: Identification of a novel class of opioid receptors

L. Gráf, Karoly Horvath, Erzsebet Walcz, Ilona Berzetei, John Burnier

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two synthetic peptides containing residues 43-47 and 43-49 of α-gliadin were tested for inhibition of leukocyte migration in 47 patients with celiac disease. In nineteen patients, all on a normal diet, leukocyte migration was inhibited by the peptides and naloxone blocked this effect. In twenty-eight patients (24 of whom were on strict gluten-free diet) leukocyte migration was not affected by the peptides. Our results suggest that α-gliadin-(43-49), Tyr-Pro-Gln-Pro-Gln-Pro-Phe, is closely related to the active fragment, or to one of the active fragments of α-gliadin, and that it interacts with receptors that are similar to but not identical with the known opiate receptors.

Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalNeuropeptides
Volume9
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Gliadin
Lymphocytes
Celiac Disease
Opioid Receptors
alpha-gliadin (43-49)
Leukocytes
Nutrition
Peptides
Gluten-Free Diet
Glutens
Naloxone
Diet

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Effect of two synthetic α-gliadin peptides on lymphocytes in celiac disease : Identification of a novel class of opioid receptors. / Gráf, L.; Horvath, Karoly; Walcz, Erzsebet; Berzetei, Ilona; Burnier, John.

In: Neuropeptides, Vol. 9, No. 2, 1987, p. 113-122.

Research output: Contribution to journalArticle

Gráf, L. ; Horvath, Karoly ; Walcz, Erzsebet ; Berzetei, Ilona ; Burnier, John. / Effect of two synthetic α-gliadin peptides on lymphocytes in celiac disease : Identification of a novel class of opioid receptors. In: Neuropeptides. 1987 ; Vol. 9, No. 2. pp. 113-122.
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