Effect of triiodothryonine on the muscarinic receptors and acetylcholinesterase activity of developing rat brain

G. N. Moskovkin, M. Kálmán, J. Kardos, K. N. Yarigin, F. Hajós

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of triiodothyronine was investigated on the developing muscarinic system in rat cerebral cortex. Triiodothyronine was administered from birth to day 30. In the synaptosomal membrane fraction of the cerebral cortex, acethylcholinesterase activity and the binding of the muscarinic ligand 3H-quinuclydinylbenzylate increased significantly as compared to the control. An analysis of the binding curve based on Hill plots suggested a positive cooperativity of receptors of the membrane samples obtained from both hormone treated and control animals. The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalInternational Journal of Neuroscience
Volume44
Issue number1-2
DOIs
Publication statusPublished - 1989

Fingerprint

Triiodothyronine
Muscarinic Receptors
Acetylcholinesterase
Cerebral Cortex
Cholinergic Agents
Membranes
Brain
Thyroid Hormones
Central Nervous System
Parturition
Hormones
Ligands

Keywords

  • Acetylcholinesterase
  • Developing brain
  • Muscarinic receptors
  • Triiodothyronine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of triiodothryonine on the muscarinic receptors and acetylcholinesterase activity of developing rat brain. / Moskovkin, G. N.; Kálmán, M.; Kardos, J.; Yarigin, K. N.; Hajós, F.

In: International Journal of Neuroscience, Vol. 44, No. 1-2, 1989, p. 83-89.

Research output: Contribution to journalArticle

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AU - Hajós, F.

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