Effect of treatment with certain flavonoids on Mengo virus-induced encephalitis in mice

Anneliese Veckenstedt, Ilona Béládi, Ilona Mucsi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Among the four flavonoids tested quercetin and morin proved to be significantly effective against lethal Mengo virus-induced encephalitis in mice when the drugs were administered orally (p.o.). With subcutaneous (s.c.) administration all four drugs failed to prevent mortality in the infected mice. Quercetin produced maximum protective response in intraperitoneally (i.p.) or intranasally (i.nas.) infected mice when administered twice daily at doses of 20 mg/kg for a period of not less than four days. Single injections of the full daily dose of drug failed to prevent deaths in mice. Treatment must be begun at the time of, or prior to, virus inoculation. Delayed initiation of treatment was ineffective in preventing mortality.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalArchives of virology
Volume57
Issue number3
DOIs
Publication statusPublished - Sep 1 1978

ASJC Scopus subject areas

  • Virology

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