Effect of transganglionic degenerative atrophy on opiate receptors in the dorsal horn of the spinal cord

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We investigated alterations in opiate‐binding sites in the upper dorsal horn after transection of the related peripheral sensory nerve in rats. The binding of (3H)diprenorphine was measured autoradiographically. The findings indicated a shift of the binding sites, rather than a degenerating disappearance, with a decrease in nerve fibers but an increase in nerve cells. This may be due to latent opiate‐binding sites becoming manifest.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalJournal of Neuroscience Research
Issue number4
Publication statusPublished - 1982



  • atrophy
  • opiate receptors
  • spinal cord
  • transganglionic degeneration

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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