Effect of transganglionic degenerative atrophy on opiate receptors in the dorsal horn of the spinal cord

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Abstract

We investigated alterations in opiate‐binding sites in the upper dorsal horn after transection of the related peripheral sensory nerve in rats. The binding of (3H)diprenorphine was measured autoradiographically. The findings indicated a shift of the binding sites, rather than a degenerating disappearance, with a decrease in nerve fibers but an increase in nerve cells. This may be due to latent opiate‐binding sites becoming manifest.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalJournal of Neuroscience Research
Volume8
Issue number4
DOIs
Publication statusPublished - 1982

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Keywords

  • atrophy
  • opiate receptors
  • spinal cord
  • transganglionic degeneration

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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