Effect of transfusion on the endothelium dependent dilatation of brachial artery in patients with chronic anemia

Lajos Nagy, Kálmán Tóth, Erzsébet Roth, Jeno Tarján

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of changes in the main determinants of whole blood viscosity after red blood cell transfusion on endothelium dependent dilatation of brachial artery was studied in patients treated with symptoms of chronic anemia. 10 patients were involved in the study, 8 males, 2 females, mean age 52.7 ± 18.7 years. Following blood tests performed at hospital admission: hemoglobin (Hgb), red blood cell count (RBC), hematocrit (Hct), white blood cell count, platelet count, plasma total protein, fibrinogen, plasma viscosity, BUN, creatinine, cholesterol, triglycerides. Flow mediated dilatation of brachial artery (FMD) was determined by Doppler method. Blood tests and FMD study were repeated after transfusion. The main determinants of whole blood viscosity increased after transfusion. The increases of Hgb, RBC, Htc were highly significant. The central flow velocity in brachial artery decreased at rest and during hyperemia as well. FMD of brachial artery was not changed significantly after transfusion. The change in factors determining whole blood viscosity did not cause a significant change in FMD. The probable explanation for this is that the increase of whole blood viscosity is associated with a decrease of central flow velocity. These two counteracting changes can equal each other.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalClinical Hemorheology and Microcirculation
Volume20
Issue number3
Publication statusPublished - 1999

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Blood Viscosity
Brachial Artery
Endothelium
Anemia
Dilatation
Erythrocyte Count
Hematologic Tests
Hemoglobins
Erythrocyte Transfusion
Blood Urea Nitrogen
Hyperemia
Platelet Count
Leukocyte Count
Hematocrit
Viscosity
Fibrinogen
Blood Proteins
Creatinine
Triglycerides
Cholesterol

Keywords

  • Blood viscosity
  • Endothelium
  • Flow mediated dilatation

ASJC Scopus subject areas

  • Hematology
  • Physiology

Cite this

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abstract = "The effect of changes in the main determinants of whole blood viscosity after red blood cell transfusion on endothelium dependent dilatation of brachial artery was studied in patients treated with symptoms of chronic anemia. 10 patients were involved in the study, 8 males, 2 females, mean age 52.7 ± 18.7 years. Following blood tests performed at hospital admission: hemoglobin (Hgb), red blood cell count (RBC), hematocrit (Hct), white blood cell count, platelet count, plasma total protein, fibrinogen, plasma viscosity, BUN, creatinine, cholesterol, triglycerides. Flow mediated dilatation of brachial artery (FMD) was determined by Doppler method. Blood tests and FMD study were repeated after transfusion. The main determinants of whole blood viscosity increased after transfusion. The increases of Hgb, RBC, Htc were highly significant. The central flow velocity in brachial artery decreased at rest and during hyperemia as well. FMD of brachial artery was not changed significantly after transfusion. The change in factors determining whole blood viscosity did not cause a significant change in FMD. The probable explanation for this is that the increase of whole blood viscosity is associated with a decrease of central flow velocity. These two counteracting changes can equal each other.",
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AU - Tóth, Kálmán

AU - Roth, Erzsébet

AU - Tarján, Jeno

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N2 - The effect of changes in the main determinants of whole blood viscosity after red blood cell transfusion on endothelium dependent dilatation of brachial artery was studied in patients treated with symptoms of chronic anemia. 10 patients were involved in the study, 8 males, 2 females, mean age 52.7 ± 18.7 years. Following blood tests performed at hospital admission: hemoglobin (Hgb), red blood cell count (RBC), hematocrit (Hct), white blood cell count, platelet count, plasma total protein, fibrinogen, plasma viscosity, BUN, creatinine, cholesterol, triglycerides. Flow mediated dilatation of brachial artery (FMD) was determined by Doppler method. Blood tests and FMD study were repeated after transfusion. The main determinants of whole blood viscosity increased after transfusion. The increases of Hgb, RBC, Htc were highly significant. The central flow velocity in brachial artery decreased at rest and during hyperemia as well. FMD of brachial artery was not changed significantly after transfusion. The change in factors determining whole blood viscosity did not cause a significant change in FMD. The probable explanation for this is that the increase of whole blood viscosity is associated with a decrease of central flow velocity. These two counteracting changes can equal each other.

AB - The effect of changes in the main determinants of whole blood viscosity after red blood cell transfusion on endothelium dependent dilatation of brachial artery was studied in patients treated with symptoms of chronic anemia. 10 patients were involved in the study, 8 males, 2 females, mean age 52.7 ± 18.7 years. Following blood tests performed at hospital admission: hemoglobin (Hgb), red blood cell count (RBC), hematocrit (Hct), white blood cell count, platelet count, plasma total protein, fibrinogen, plasma viscosity, BUN, creatinine, cholesterol, triglycerides. Flow mediated dilatation of brachial artery (FMD) was determined by Doppler method. Blood tests and FMD study were repeated after transfusion. The main determinants of whole blood viscosity increased after transfusion. The increases of Hgb, RBC, Htc were highly significant. The central flow velocity in brachial artery decreased at rest and during hyperemia as well. FMD of brachial artery was not changed significantly after transfusion. The change in factors determining whole blood viscosity did not cause a significant change in FMD. The probable explanation for this is that the increase of whole blood viscosity is associated with a decrease of central flow velocity. These two counteracting changes can equal each other.

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KW - Flow mediated dilatation

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