Effect of toluene exposure on the liver under different experimental conditions

György Ungváry, E. Tátrai, Szabolcs Szeberényi, Katalin Rodics, Miklos Lörincz, Gyöngyi Barcza

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of exposure to toluene inhalation was studied in adult mice, rats, and rabbits, and, further, in rats of different age groups and rats subjected to partial hepatectomy or ligation of the common bile duct. It was found that (1) toluene has no substantial liver damaging effect on the mouse, rat, or rabbit; (2) induction of microsomal monooxygenase enzymes by toluene is almost completely independent of physiological changes affecting the functional-anatomical state of the liver (aging), of restriction of the functional capacity of the organ (partial hepatectomy), and of irreversible hepatic damage (bile duct ligation); (3) toluene does not in any way interfere with surgically induced hepatic damage. The consequences of surgical interventions, in turn, just like the age-dependent changes, do not modify the minimal ultrastructural damaging effect of toluene.

Original languageEnglish
Pages (from-to)347-360
Number of pages14
JournalExperimental and Molecular Pathology
Volume36
Issue number3
DOIs
Publication statusPublished - 1982

Fingerprint

Toluene
Liver
Rats
Hepatectomy
Ducts
Ligation
Rabbits
Aryl Hydrocarbon Hydroxylases
Common Bile Duct
Bile Ducts
Inhalation
Age Groups
Aging of materials
Enzymes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Effect of toluene exposure on the liver under different experimental conditions. / Ungváry, György; Tátrai, E.; Szeberényi, Szabolcs; Rodics, Katalin; Lörincz, Miklos; Barcza, Gyöngyi.

In: Experimental and Molecular Pathology, Vol. 36, No. 3, 1982, p. 347-360.

Research output: Contribution to journalArticle

Ungváry, György ; Tátrai, E. ; Szeberényi, Szabolcs ; Rodics, Katalin ; Lörincz, Miklos ; Barcza, Gyöngyi. / Effect of toluene exposure on the liver under different experimental conditions. In: Experimental and Molecular Pathology. 1982 ; Vol. 36, No. 3. pp. 347-360.
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