Effect of time of day and fasting duration on measures of glycaemia: Analysis from the Whitehall II Study

A. Hulmán, K. Færch, D. Vistisen, J. Karsai, T. Nyári, A. Tabák, E. J. Brunner, M. Kivimäki, D. R. Witte

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims/hypothesis: We aimed to study diurnal variation in glucose regulation by examining the effects of time of day and fasting duration on fasting plasma glucose (FPG), 2 h post-load plasma glucose (2hPG) and HbA1c levels. Methods: We analysed data from 5,978 non-diabetic white men and women from the prospective Whitehall II Study. All studied participants fasted for at least 8 h before a clinical examination, which included an OGTT and anthropometric measurements. We fitted mixed-effects models for FPG, 2hPG and HbA1c as outcome variables, and time of day and/or fasting duration as explanatory variables. Models were adjusted for age, BMI and study phase. Results: Time of day and fasting duration were associated inversely with FPG and positively with 2hPG. The mean difference between measures at 08:00 and 15:00 hours in men/women was -0.46 (95% CI -0.50, -0.42) mmol/l/-0.39 (95% CI -0.46, -0.31) mmol/l and 1.39 (95% CI 1.25, 1.52) mmol/l/1.19 (95% CI 0.96, 1.42) mmol/l for FPG and 2hPG, respectively. HbA1c levels were independent of either time. Time of day and fasting duration were independently associated with 2hPG. In contrast, the effect of fasting duration on FPG was markedly attenuated with adjustment for time of day. Ageing, but not obesity, was associated with increased diurnal variation in glucose tolerance. Conclusions/interpretation: Both time of day and fasting duration should be considered in clinical practice and epidemiological studies, since they have clinically relevant effects on FPG and 2hPG levels. As biochemically expected, HbA1c levels are independent of time of blood sampling and fasting duration.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalDiabetologia
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Fasting
Glucose
Glucose Tolerance Test
Epidemiologic Studies
Obesity

Keywords

  • Diurnal variation
  • Fasting duration
  • HbA
  • Oral glucose tolerance test

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of time of day and fasting duration on measures of glycaemia : Analysis from the Whitehall II Study. / Hulmán, A.; Færch, K.; Vistisen, D.; Karsai, J.; Nyári, T.; Tabák, A.; Brunner, E. J.; Kivimäki, M.; Witte, D. R.

In: Diabetologia, Vol. 56, No. 2, 02.2013, p. 294-297.

Research output: Contribution to journalArticle

Hulmán, A, Færch, K, Vistisen, D, Karsai, J, Nyári, T, Tabák, A, Brunner, EJ, Kivimäki, M & Witte, DR 2013, 'Effect of time of day and fasting duration on measures of glycaemia: Analysis from the Whitehall II Study', Diabetologia, vol. 56, no. 2, pp. 294-297. https://doi.org/10.1007/s00125-012-2770-3
Hulmán, A. ; Færch, K. ; Vistisen, D. ; Karsai, J. ; Nyári, T. ; Tabák, A. ; Brunner, E. J. ; Kivimäki, M. ; Witte, D. R. / Effect of time of day and fasting duration on measures of glycaemia : Analysis from the Whitehall II Study. In: Diabetologia. 2013 ; Vol. 56, No. 2. pp. 294-297.
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AU - Karsai, J.

AU - Nyári, T.

AU - Tabák, A.

AU - Brunner, E. J.

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