Effect of thirsting on the biological half-life and organ-distribution of 3H-lysin vasopressin

F. A. Laszlo, E. Nagy, L. Gaspar, G. Kéri, I. Teplán

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The biological half-life and organ-distribution of radiochemically pure, biologically active 3H-LVP were determined in normally hydrated and in thirsting rats. Three-day thirsting did not vary the biological half-life of the 3H-LVP. The highest 3H-LVP uptake was observed in the neurohypophysis and adenohypophysis of the normally hydrated rats. As a result of thirsting, the accumulation of labelled vasopressin was increased in the neurohypophysis. The results permit the conclusion that the uptake of vasopressin by the neurohypophysis of rat is enhanced at the time of exocytosis and microvesicle formation induced by dehydration.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalHormone and Metabolic Research
Volume12
Issue number9
Publication statusPublished - Dec 1 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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