Effect of the types and arrangements of donor atoms on Pb(II) versus Zn(II) binding preference of selected amino acids, peptides and derivatives

Etelka Farkas, Beáta Bóka, Béla Szocs, Attila J. Godó, Imre Sóvágó

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Pb(II) complexes in solution formed with different amino acids [glycine (Gly), aspartic acid (Asp), histidine (His), methionine (Met), S-methyl-cysteine (SMC) and penicillamine (Pen)], dipeptides (GlyGly, GlyVal (Val = valine), GlyMet, MetGly, GlyHis, HisGly, GlyAsp, AspGly, CysGly (Cys = cysteine), AlaCys, GlyGlu (Glu = glutamic acid), GluVal, SerGly (Ser = serine)), tripeptides (GlyGlyGly, GlyMetGly, GlyGlyMet, MetMetMet), as well as two peptidehydroxamic acids [(alanyl-alanine hydroxamic acid (AlaAlaNHOH) and N-methyl-alanyl-alanine hydroxamic acid AlaAlaN(CH3)OH)] have been studied by pH-potentiometry, 1H NMR and ESI-MS measurements. The effects of the types and arrangements of the donor atoms on the Pb(II)-binding ability as well as on the selectivity for Pb(II) over Zn(II) were evaluated. Out of the investigated molecules, the Pb(II) binding ability of Pen is far the best, but compared to this ligand, somewhat better selectivity for Pb(II) over Zn(II) can be achieved with S-containing dipeptides.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalInorganica Chimica Acta
Issue numberPA
Publication statusPublished - Nov 1 2014



  • Amino acid
  • Aminohydroxamic acid
  • Pb(II)
  • Peptides
  • Selectivity over Zn(II)

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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