VPG-s (Vesicular Phospholipid Gel) are semisolid systems, which provide suitable stable form for preparation and storage of liposomes. Aim of our study was preparing fully hydrated lecithin and sterol containing VPG-s by high pressure homogenization. Structure examination of the gels and the redispersed systems occured by polarizing microscopy, differential scanning calorimetry (DSC), cryoelectron-microscopy and photon correlation spectroscopy (PCS). It was found that the obtained gel systems consist of mainly small unilamellar vesicles. With increased sterol content in the liposome membrane the fluidity and dispersity of the systems were increased. It could be also observed that the effect of β-sitosterol on the bilayer was slightly greater than that of cholesterol.
|Translated title of the contribution||Effect of the sterol content on the structure of vesicular phospholipid gels|
|Number of pages||5|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Jul 26 2004|
ASJC Scopus subject areas
- Pharmaceutical Science