Szterin-tartalom hatása vezikuláris foszfolipid gélek szerkezetére

Translated title of the contribution: Effect of the sterol content on the structure of vesicular phospholipid gels

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

VPG-s (Vesicular Phospholipid Gel) are semisolid systems, which provide suitable stable form for preparation and storage of liposomes. Aim of our study was preparing fully hydrated lecithin and sterol containing VPG-s by high pressure homogenization. Structure examination of the gels and the redispersed systems occured by polarizing microscopy, differential scanning calorimetry (DSC), cryoelectron-microscopy and photon correlation spectroscopy (PCS). It was found that the obtained gel systems consist of mainly small unilamellar vesicles. With increased sterol content in the liposome membrane the fluidity and dispersity of the systems were increased. It could be also observed that the effect of β-sitosterol on the bilayer was slightly greater than that of cholesterol.

Translated title of the contributionEffect of the sterol content on the structure of vesicular phospholipid gels
Original languageHungarian
Pages (from-to)118-122
Number of pages5
JournalActa pharmaceutica Hungarica
Volume74
Issue number2
Publication statusPublished - Jul 26 2004

ASJC Scopus subject areas

  • Pharmaceutical Science

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