Effect of the solvent on enzyme enantioselectivity

Research output: Contribution to journalArticle

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Abstract

The Candida cylindracea lipase catalyzed enantioselective esterification of 2-chloropropionic acid was studied in different solvents with constant initial water content in the reaction mixture. The effect of solvents and solvent mixtures with different hydrophobicity (e.g. log P value) on the activity and enantioselectivity of the enzyme was investigated. The log P values showed a linear correlation with the initial reaction rate as well as with the enantioselectivity. The rate increased while the enantioselectivity slightly decreased with increasing log P values. In solvent mixtures the activity of the enzyme was generally determined by the solvent with the lowest hydrophobicity while the correlation between the average log P value and the enantioselectivity was linear.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalProgress in Biotechnology
Volume8
Issue numberC
DOIs
Publication statusPublished - Jan 1 1992

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Enzymes
Hydrophobic and Hydrophilic Interactions
Esterification
Lipase
Candida
Water
2-chloropropionic acid

ASJC Scopus subject areas

  • Biotechnology

Cite this

Effect of the solvent on enzyme enantioselectivity. / Gubicza, L.

In: Progress in Biotechnology, Vol. 8, No. C, 01.01.1992, p. 497-503.

Research output: Contribution to journalArticle

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