Effect of the sesterterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi

Krisztina Krizsán, Ottó Bencsik, Ildikó Nyilasi, László Galgóczy, Csaba Vágvölgyi, Tamás Papp

Research output: Contribution to journalLetter

16 Citations (Scopus)

Abstract

Ophiobolins are sesterterpene-type phytotoxins produced by fungi belonging mainly to the genus Bipolaris. In this study, the antifungal effect of ophiobolins A and B on different zygomycetes has been examined. Depending on the zygomycete tested, MIC values of 3.175-50 μg mL-1 were found for ophiobolin A and 25-50 μg mL-1 for ophiobolin B. Ophiobolin A inhibited sporangiospore germination of Mucor circinelloides and caused morphological changes; the fungus formed degenerated, thick or swollen cells with septa. Cytoplasm effusions from the damaged cells were also observed. Fluorescence microscopy after annexin and propidium iodide staining of the treated cells suggested that the drug induced an apoptosis-like cell death process in the fungus.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalFEMS microbiology letters
Volume313
Issue number2
DOIs
Publication statusPublished - Dec 1 2010

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Keywords

  • Antifungal susceptibility
  • Apoptosis
  • Calmodulin
  • Mucor
  • Ophiobolin

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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