Effect of the number of uninvolved nodes on survival in early breast cancer

Vincent Vinh-Hung, G. Cserni, Tomasz Burzykowski, Jan Van De Steene, Mia Voordeckers, Guy Storme

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A high number of uninvolved axillary nodes was found by some authors to be associated with poor survival in node-negative breast cancer. We searched for confirmation and extend the investigation to node-positive cases, using population data from the SEER Program. Patients selected were women aged 40-69 years, diagnosed 1988-1997, T1-T2 breast cancer, undergoing axillary dissection with 4-35 nodes examined. Survivals were estimated by the product-limit method and were computed on pooled data. Results in node-negative patients (n=37,5 1 9) showed a 5-year overall survival from 92% (95% confidence interval: 88-95%) with 4 uninvolved nodes, to 93% (87-98%) with 34 uninvolved nodes. In node-positive patients (n=16,978), the 5-year survival increased from 50% (44-56%) with 0 uninvolved nodes, to 91% (82-100%) with 30 uninvolved nodes. Survival graphs indicated an improvement or a plateau with higher number of uninvolved nodes. The graphs also suggested that the ratio of involved and uninvolved nodes might be correlated with survival. We conclude that there was no evidence of poor outcome associated with a high number of uninvolved nodes. The incidental finding that ratio-based characterisation of node involvement might be a prognostic factor will be further investigated.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalOncology Reports
Volume10
Issue number2
Publication statusPublished - Mar 2003

Fingerprint

Breast Neoplasms
Survival
SEER Program
Incidental Findings
Kaplan-Meier Estimate
Dissection
Confidence Intervals
Population

Keywords

  • Axilla
  • Biological
  • Breast neoplasms
  • Diagnostic techniques
  • Dissection
  • Lymph nodes
  • Models
  • Neoplasm staging
  • Prognosis
  • Ratio-based staging
  • SEER program
  • Surgical
  • Survival analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Vinh-Hung, V., Cserni, G., Burzykowski, T., Van De Steene, J., Voordeckers, M., & Storme, G. (2003). Effect of the number of uninvolved nodes on survival in early breast cancer. Oncology Reports, 10(2), 363-368.

Effect of the number of uninvolved nodes on survival in early breast cancer. / Vinh-Hung, Vincent; Cserni, G.; Burzykowski, Tomasz; Van De Steene, Jan; Voordeckers, Mia; Storme, Guy.

In: Oncology Reports, Vol. 10, No. 2, 03.2003, p. 363-368.

Research output: Contribution to journalArticle

Vinh-Hung, V, Cserni, G, Burzykowski, T, Van De Steene, J, Voordeckers, M & Storme, G 2003, 'Effect of the number of uninvolved nodes on survival in early breast cancer', Oncology Reports, vol. 10, no. 2, pp. 363-368.
Vinh-Hung V, Cserni G, Burzykowski T, Van De Steene J, Voordeckers M, Storme G. Effect of the number of uninvolved nodes on survival in early breast cancer. Oncology Reports. 2003 Mar;10(2):363-368.
Vinh-Hung, Vincent ; Cserni, G. ; Burzykowski, Tomasz ; Van De Steene, Jan ; Voordeckers, Mia ; Storme, Guy. / Effect of the number of uninvolved nodes on survival in early breast cancer. In: Oncology Reports. 2003 ; Vol. 10, No. 2. pp. 363-368.
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