Effect of the formulation parameters on the characteristics of pellets

R. Fekete, R. Zelkó, S. Marton, I. Rácz

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Pelletization is increasingly applied currently for the preparation of solid oral controlled-release dosage forms. The production of the particles, which are regular in shape and size, can be achieved with the application of the proper polymer auxiliary materials and new pharmaceutical technological methods (extrusion, spheronization). Regularity in shape and size, attained by the optimization of several production parameters, can promote the coating procedure. Under optimal conditions, particles were prepared for coating in a high-shear mixer, which is used to produce uniform particles. The effect of the rotating speed of the applied chopper and the amount of microcrystalline cellulose in the composition on the physical characteristics of the pellets was modeled by a second-order polynomial equation fitted to the data gathered by a face-centered central composite statistical design.

Original languageEnglish
Pages (from-to)1073-1076
Number of pages4
JournalDrug Development and Industrial Pharmacy
Volume24
Issue number11
Publication statusPublished - 1998

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Coatings
Dosage Forms
Extrusion
Polymers
Polynomials
Composite materials
Chemical analysis
Pharmaceutical Preparations
microcrystalline cellulose

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Effect of the formulation parameters on the characteristics of pellets. / Fekete, R.; Zelkó, R.; Marton, S.; Rácz, I.

In: Drug Development and Industrial Pharmacy, Vol. 24, No. 11, 1998, p. 1073-1076.

Research output: Contribution to journalArticle

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