Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s4dU)35]

András Horváth, Zoltán Beck, Thomas J. Bardos, Joseph A. Dunn, J. Aradi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Suligovir is a 35-mer homo-oligonucleotide, containing exclusively 4-thio deoxyuridylate, proved to be a potent inhibitor of HIV entry. In this paper, we described the effect of extent of thiolation and the introduction of nuclease-resistant phosphorothioate linkages on the anti-HIV activity of Suligovir. We found that the decreased thiolated nucleotide content decreases the anti-HIV potency of the compound and the introduction of phosphorothioate linkages does not improve its antiviral activity.

Original languageEnglish
Pages (from-to)5321-5323
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number20
DOIs
Publication statusPublished - Oct 15 2006

Fingerprint

HIV Fusion Inhibitors
HIV
Oligonucleotides
Antiviral Agents
Nucleotides
(s4dU)35

Keywords

  • 4-Thio-oligo-deoxyuridylate
  • Anti-HIV
  • Chemically modified oligonucleotides
  • HIV
  • HIV entry
  • Suligovir

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s4dU)35]. / Horváth, András; Beck, Zoltán; Bardos, Thomas J.; Dunn, Joseph A.; Aradi, J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 20, 15.10.2006, p. 5321-5323.

Research output: Contribution to journalArticle

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