Effect of the combination of suspending agents on the dissolution and stability of an albendazole suspension

E. Biró, I. Antal, I. Rácz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The combined effect of a negatively charged hydrophylic polymer (sodium carboxymethylcellulose, NaCMC) and a nonionic polymer (methylhydroxyethylcellulose, MHEC) was studied with regard to the dissolution and stability of albendazole-containing suspensions. The amount of drug dissolved was increased about four-fold and the dissolution rate ten- fold when compared with milled albendazole with suspending agents at the optimal ratio determined. Although the suspension achieved with MHEC had a lower viscosity and more rapid sedimentation rate, this was balanced by NaCMC in the combined formulations.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalS.T.P. Pharma Sciences
Volume10
Issue number2
Publication statusPublished - Mar 2000

Fingerprint

Albendazole
Excipients
Suspensions
Polymers
Carboxymethylcellulose Sodium
Viscosity
Pharmaceutical Preparations
methyl hydroxyethyl cellulose

Keywords

  • Albendazole suspensions
  • Combination of viscosity increasing agents
  • Enhanced drug dissolution
  • Methylhydroxyethyl cellulose
  • Physical stability
  • Sodium carboxymethylcellulose

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effect of the combination of suspending agents on the dissolution and stability of an albendazole suspension. / Biró, E.; Antal, I.; Rácz, I.

In: S.T.P. Pharma Sciences, Vol. 10, No. 2, 03.2000, p. 195-198.

Research output: Contribution to journalArticle

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