Effect of the anti-oestrogen Tamoxifen on the development of renal cortical necrosis induced by oestrone+vasopressin administration in rats

J. Kocsis, G. Karacsony, S. Karcsu, F. László

Research output: Contribution to journalArticle

Abstract

Bilateral renal cortical necrosis was observed after vasopressin administration in rats pretreated with oestrone acetate. Histochemical (succinic dehydrogenase , trichrome, periodic acid Schiff) and electronmicroscopic methods were used to examine how the anti-oestrogen, Tamoxifen, influences the development of this renal cortical necrosis. The experiments revealed that in most rats vasopressin did not induce renal tubular necrosis if the anti-oestrogen was administered simultaneously, even during oestrogen pretreatment. The results suggest that oestrogen receptors in the kidney are involved in the induction of renal cortical necrosis by vasopressin.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalBritish Journal of Experimental Pathology
Volume69
Issue number2
Publication statusPublished - 1988

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Kidney Cortex Necrosis
Estrone
Tamoxifen
Vasopressins
Estrogens
Kidney
Periodic Acid
Succinate Dehydrogenase
Estrogen Receptors
Necrosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Effect of the anti-oestrogen Tamoxifen on the development of renal cortical necrosis induced by oestrone+vasopressin administration in rats. / Kocsis, J.; Karacsony, G.; Karcsu, S.; László, F.

In: British Journal of Experimental Pathology, Vol. 69, No. 2, 1988, p. 157-168.

Research output: Contribution to journalArticle

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