The isocratic retention of cyclic β-amino acids is studied on a chiral crown ether column (Crownpak CR[+]) at different temperatures. The natural logarithm of the retention factor (In k) depends linearly on the inverse of temperature (1/T). van't Hoff plots afford thermodynamic parameters, such as the apparent change of enthalpy (ΔHo) and the apparent change of entropy (ΔSo) for the transfer of analyte from the mobile phase to the stationary phase. The information obtained from the thermodynamic study is discussed, and the qualitative relationships between the structure and the thermodynamic data are evaluated.
ASJC Scopus subject areas
- Analytical Chemistry