Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats

G. Csaba, Cs Karabélyos, Ágnes Inczefi-Gonda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hormonal imprinting takes place perinatally, at the first encounter between the target hormone and its developing receptor. However, there is a secondary critical period of imprinting at puberty. In these periods molecules similar to the hormones (members of the same hormone family, antagonists, certain environmental pollutants, etc.) can cause faulty imprinting with lifelong consequences. In the present experiments 5+2 days of tamoxifen treatment (120 μg/day) at adolescent age dramatically (from approx. 40% to 10%) reduced the sexual activity (Meyers on index and lordosis quotient) of female rats, soon after the finishment of the treatment and between four to six weeks after treatment. Similar results were observed in animals neonatally treated with allylestrenol and tamoxifen treated at puberty. Thymic glucocorticoid receptor and uterine estrogen receptor binding capacity were not influenced.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalActa Physiologica Hungarica
Volume88
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Steroid Receptors
Tamoxifen
Sexual Behavior
Hormones
Puberty
Allylestrenol
Hormone Antagonists
Lordosis
Environmental Pollutants
Glucocorticoid Receptors
Estrogen Receptors
Therapeutics
Imprinting (Psychology)

Keywords

  • Estrogen receptors
  • Glucocorticoid receptors
  • Hormonal imprinting
  • Sexual behavior
  • Tamoxifen

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats. / Csaba, G.; Karabélyos, Cs; Inczefi-Gonda, Ágnes.

In: Acta Physiologica Hungarica, Vol. 88, No. 2, 2001, p. 131-137.

Research output: Contribution to journalArticle

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