Effect of surgical isolation of the hypothalamus on its neurotransmitter content

Michael J. Brownstein, Miklos Palkovits, Marcel L. Tappaz, Juan M. Saavedra, J. Stephen Kizer

Research output: Contribution to journalArticle

106 Citations (Scopus)


The concentrations of norepinephrine, dopamine-β-hydroxylase, dopamine, tyrosine hydroxylase, phenylethanolamine-N-methyltransferase, serotonin, tryptophan hydroxylase, histamine, glutamic acid decarboxylase, and choline acetyltransferase were determined in selected hypothalamic nuclei and in the median eminence after deafferentation of the medial basal hypothalamus. Norepinephrine and dopamine-β-hydroxylase fell markedly while dopamine and tyrosine hydroxylase did not. Serotonin also decreased in all regions studied; histamine decreased in none. Choline acetyltransferase, phenylethanolamine-N-methyltransferase, and glutamic acid decarboxylase declined in some areas, but not in others.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalBrain research
Issue number2
Publication statusPublished - Nov 26 1976

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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