Effect of suramin (Bayer 205) on renal ornithine decarboxylase activity and polyamine concentrations in rats

Laszlo Selmeci, Elek Posch, Gyorgy Simon, Laszlo Harsing

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

After a single high dose (20 mg/100 g i.v.) of suramin ornithine decarboxylase activity was increased rapidly in the rat kidney. Enzyme kinetic measurements indicate that on the basis of Km values renal ornithine decarboxylases from control or suramin treated rats are indistinguishable. Renal nucleic acid and polyamine levels were also enhanced in response to suramin. Changes observed in this study are considered as biochemical signs of induced renal growth.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalBiochemical and biophysical research communications
Volume87
Issue number1
DOIs
Publication statusPublished - Mar 15 1979

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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