Effect of support characteristics on the determination of the lipophilicity of some neutral, acidic and alkaline compounds by reversed-phase thin-layer chromatography

Tibor Cserháti, Yassin M. Darwish, Gyorgy Matolcsy

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The lipophilicity of some neutral, acidic and alkaline compounds was determined by reversed-phase thin-layer chromatography applying silica, aluminium oxide and cellulose in different degrees impregnated with paraffin oil as support. The lipophilicity of all compounds increased on all supports at increasing extent of impregnation; paraffin oil gradually covered the active adsorption sites of supports. The lowest RM values were determined on cellulose support owing to its lower adsorptive capacity. The alkaline compounds showed higher RM values on silica and the acidic compounds on aluminium oxide, proving that also the surface pH value of the support influences the lipophilicity determination.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalJournal of Chromatography A
Issue numberC
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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