Effect of support characteristics on the determination of the lipophilicity of some neutral, acidic and alkaline compounds by reversed-phase thin-layer chromatography

T. Cserháti, Yassin M. Darwish, Gyorgy Matolcsy

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Abstract

The lipophilicity of some neutral, acidic and alkaline compounds was determined by reversed-phase thin-layer chromatography applying silica, aluminium oxide and cellulose in different degrees impregnated with paraffin oil as support. The lipophilicity of all compounds increased on all supports at increasing extent of impregnation; paraffin oil gradually covered the active adsorption sites of supports. The lowest RM values were determined on cellulose support owing to its lower adsorptive capacity. The alkaline compounds showed higher RM values on silica and the acidic compounds on aluminium oxide, proving that also the surface pH value of the support influences the lipophilicity determination.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalJournal of Chromatography A
Volume270
Issue numberC
DOIs
Publication statusPublished - 1983

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Thin layer chromatography
Aluminum Oxide
Reverse-Phase Chromatography
Thin Layer Chromatography
Cellulose
Silicon Dioxide
Impregnation
Adsorption
Catalytic Domain
paraffin oils

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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abstract = "The lipophilicity of some neutral, acidic and alkaline compounds was determined by reversed-phase thin-layer chromatography applying silica, aluminium oxide and cellulose in different degrees impregnated with paraffin oil as support. The lipophilicity of all compounds increased on all supports at increasing extent of impregnation; paraffin oil gradually covered the active adsorption sites of supports. The lowest RM values were determined on cellulose support owing to its lower adsorptive capacity. The alkaline compounds showed higher RM values on silica and the acidic compounds on aluminium oxide, proving that also the surface pH value of the support influences the lipophilicity determination.",
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T1 - Effect of support characteristics on the determination of the lipophilicity of some neutral, acidic and alkaline compounds by reversed-phase thin-layer chromatography

AU - Cserháti, T.

AU - Darwish, Yassin M.

AU - Matolcsy, Gyorgy

PY - 1983

Y1 - 1983

N2 - The lipophilicity of some neutral, acidic and alkaline compounds was determined by reversed-phase thin-layer chromatography applying silica, aluminium oxide and cellulose in different degrees impregnated with paraffin oil as support. The lipophilicity of all compounds increased on all supports at increasing extent of impregnation; paraffin oil gradually covered the active adsorption sites of supports. The lowest RM values were determined on cellulose support owing to its lower adsorptive capacity. The alkaline compounds showed higher RM values on silica and the acidic compounds on aluminium oxide, proving that also the surface pH value of the support influences the lipophilicity determination.

AB - The lipophilicity of some neutral, acidic and alkaline compounds was determined by reversed-phase thin-layer chromatography applying silica, aluminium oxide and cellulose in different degrees impregnated with paraffin oil as support. The lipophilicity of all compounds increased on all supports at increasing extent of impregnation; paraffin oil gradually covered the active adsorption sites of supports. The lowest RM values were determined on cellulose support owing to its lower adsorptive capacity. The alkaline compounds showed higher RM values on silica and the acidic compounds on aluminium oxide, proving that also the surface pH value of the support influences the lipophilicity determination.

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