Effect of sulfadiazine on biological model membranes

Ágnes Oszlánczi, Cs Novák, E. Klumpp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of sulfadiazine on dipalmitoylphosphatidylethanolamin- dipalmitoylphosphatidylglycerol-water (DPPE-DPPG/water, 20 mass/mass%, with 0.2 DPPG/DPPE+DPPG molar ratio) vesicles considered as a model system of the cytoplasmic bacterial membranes was studied using DSC and freeze-fracture methods. The sulfadiazine/lipid molar ratio was varied from 10-3 up to 1. It was found that the DPPE-DPPG/water system is drastically affected by the sulfadiazine, but there is no concentration effect in a wide range of sulfadiazine/lipid molar ratios from 10-2 up to 2•10 -1. The DSC and freeze-fracture methods reveal that a homogeneous incorporation of the sulfadiazine molecules occurs in the liquid crystalline phase while in the gel phase separation appears. The different local structures can be classified into two different types: vesicle-like and block-type. Although the surface morphology of the domains of both types shows lamellar arrangement, the blocks are constituted from closely packed long units.

Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalJournal of Thermal Analysis and Calorimetry
Volume82
Issue number2
DOIs
Publication statusPublished - Nov 1 2005

Keywords

  • DPPE-DPPG vesicles
  • DSC
  • Freeze-fracture
  • Phase separation
  • Sulfadiazine

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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