Effect of subchronic bimoclomol treatment on vascular responsiveness and heat shock protein production in spontaneously hypertensive rats

Andrea Jednákovits, István Kurucz, Péter P. Nánási

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study was designed to investigate the effects of subchronic bimoclomol treatment on endothelial function and expression of 72 kD heat shock protein (HSP-72) in spontaneously hypertensive rats. Endothelial function was tested by monitoring vascular responses to acetylcholine in isolated aortic ring preparations. Polymerase chain reaction was applied to determine HSP-72 mRNA content in the tissue samples. Significant age-dependent declines in relaxation to acetylcholine and vascular HSP-72 mRNA levels were observed in the spontaneously hypertensive animals. Both changes were prevented by subchronic application of bimoclomol suggesting that preservation of endothelial function might be related to sustained levels of HSP-72. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1791-1797
Number of pages7
JournalLife Sciences
Volume67
Issue number14
DOIs
Publication statusPublished - Aug 25 2000

    Fingerprint

Keywords

  • Bimoclomol
  • Endothelium
  • Gene expression
  • Heat shock protein
  • Hypertension
  • SH rats
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this